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Literature summary for 1.5.3.16 extracted from

  • Fiori, L.M.; Turecki, G.
    Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers (2010), Int. J. Neuropsychopharmacol., 13, 725-736.
    View publication on PubMed

Application

Application Comment Organism
medicine alterations in the levels of spermine synthase SMS and spermine oxidase SMOX have previously been observed in brains of suicide completers. SMS and SMOX display several promoter haplotypes, without consistent effects of haplotype on expression levels in either the brain or in reporter gene assays performed in three different cell lines. There are no overall effects of epigenetic factors in determining expression, with the exception of a relationship between CpG methylation at one site in the promoter of SMOX and its expression in Brodmann area 8/9. The genetic and epigenetic factors examined in this study show little influence on the expression levels of SMS and SMOX Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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Synonyms

Synonyms Comment Organism
SMOX
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Homo sapiens