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Literature summary for 1.5.3.13 extracted from

  • Bianchi, M.; Polticelli, F.; Ascenzi, P.; Botta, M.; Federico, R.; Mariottini, P.; Cona, A.
    Inhibition of polyamine and spermine oxidases by polyamine analogues (2006), FEBS J., 273, 1115-1123.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1,12-diaminododecane 1,12-diaminododecane derivatives could represent good candidates for the development of novel highly specific mPAO inhibitors Mus musculus
guazatine
-
Mus musculus
MDL72527
-
Mus musculus
additional information no inhibition at pH 7.5: 1,8-diaminooctane. Comparative study on murine PAO (mPAO) and SMO (mSMO) inhibition. The different behaviour displayed by 1,12-diaminododecane towards mPAO and mSMO reveals the occurrence of basic differences in the ligand binding mode of the two enzymes, the first enzyme interacting mainly with substrate secondary amino groups and the second one with substrate primary amino groups. The data provide the basis for the development of novel and selective inhibitors able to discriminate between mammalian SMO and PAO activities Mus musculus
N-prenylagmatine
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C0L6
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N1-acetylspermine + O2 + H2O
-
Mus musculus spermidine + 3-acetamidopropanal + H2O2
-
?

Synonyms

Synonyms Comment Organism
MPAO
-
Mus musculus
polyamine oxidase
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00045
-
guazatine pH 7.5, 25°C Mus musculus
0.0008
-
N-prenylagmatine pH 7.5, 25°C Mus musculus
0.008
-
1,12-diaminododecane pH 7.5, 25°C Mus musculus
0.021
-
MDL72527 pH 7.5, 25°C Mus musculus