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Literature summary for 1.5.3.13 extracted from

  • Vujcic, S.; Liang, P.; Diegelman, P.; Kramer, D.L.; Porter, C.W.
    Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion (2003), Biochem. J., 370, 19-28.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.3.13

Cloned(Commentary)

Cloned (Comment) Organism
cDNA is transiently transfected into HEK-293 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PAO expression is inducible by polyamine analogues and thus may contribute to the inhibition of cell growth ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6QHF9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
kidney reduced level of PAO in neoplastic tissue Homo sapiens
-
ovary reduced level of PAO in neoplastic tissue Homo sapiens
-
prostate reduced level of PAO in neoplastic tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with spermidine Homo sapiens ?
-
 ?
additional information PAO expression is inducible by polyamine analogues and thus may contribute to the inhibition of cell growth Homo sapiens ?
-
 ?
N1,N11-diethylnorspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
N1,N12-diacetylspermine + O2 + H2O N1-acetylspermine is first liberated as a product and then oxidized further to putrescine Homo sapiens N1-acetylspermidine + 3-acetamidopropanal + H2O2
-
 ?
N1,N12-diacetylspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
N1,N12-diethylspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
N1,N14-diethylhomospermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
N1-acetylspermidine + O2 + H2O
-
 Homo sapiens ?
-
 ?
N1-acetylspermidine + O2 + H2O
-
 Homo sapiens putrescine + 3-acetamidopropanal
-
 ?
N1-acetylspermine + O2 + H2O PAO preferentially oxidizes acetylspermine or acetylspermidine over spermine Homo sapiens spermidine + 3-acetamidopropanal + H2O2
-
 ?
N1-acetylspermine + O2 + H2O
-
 Homo sapiens ?
-
 ?
spermine + O2 + H2O least favoured substrate Homo sapiens spermidine + 3-aminopropanal + H2O2
-
 ?
spermine + O2 + H2O weak activity Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, calculated from sequence Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens