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Literature summary for 1.5.1.8 extracted from

  • Stepansky, A.; Galili, G.
    Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals (2003), Plant Physiol., 133, 1407-1415.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH Arabidopsis sp. the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?

Organism

Organism UniProt Comment Textmining
Arabidopsis sp.
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ecotype C-24
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH
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Arabidopsis sp. N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
?
L-lysine + 2-oxoglutarate + NADPH the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level Arabidopsis sp. N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
LKR/SDH
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Arabidopsis sp.
lysine-ketoglutarate reductase/saccharopine dehydrogenase bifunctional Arabidopsis sp.

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Arabidopsis sp.