Application | Comment | Organism |
---|---|---|
medicine | hyperlysinemia: genetic disease, deficiency of lysine-ketoglutarate reductase results in extreme elevations of serum lysine | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Sus scrofa | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
mitochondrion | - |
Ovis aries | 5739 | - |
mitochondrion | - |
Canis lupus familiaris | 5739 | - |
mitochondrion | - |
Felis catus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine + 2-oxoglutarate + NADPH | Homo sapiens | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Rattus norvegicus | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Sus scrofa | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Bos taurus | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Ovis aries | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Canis lupus familiaris | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Felis catus | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Homo sapiens | important role in the degradation of lysine | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | Rattus norvegicus Wistar | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Canis lupus familiaris | - |
mongrels | - |
Felis catus | - |
tabby | - |
Homo sapiens | - |
- |
- |
Ovis aries | - |
- |
- |
Rattus norvegicus | - |
Wistar strain | - |
Rattus norvegicus Wistar | - |
Wistar strain | - |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Ovis aries | - |
liver | - |
Canis lupus familiaris | - |
liver | - |
Felis catus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Sus scrofa |
additional information | - |
- |
Bos taurus |
additional information | - |
- |
Ovis aries |
additional information | - |
- |
Canis lupus familiaris |
additional information | - |
- |
Felis catus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Rattus norvegicus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Sus scrofa | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Bos taurus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Ovis aries | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Canis lupus familiaris | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Felis catus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Rattus norvegicus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Sus scrofa | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Bos taurus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Ovis aries | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Canis lupus familiaris | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Felis catus | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | important role in the degradation of lysine | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? | |
L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Rattus norvegicus Wistar | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Rattus norvegicus Wistar | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | saccharopine is a key intermediate in the degradative pathway of lysine metabolism | ? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Sus scrofa | |
NADPH | - |
Bos taurus | |
NADPH | - |
Ovis aries | |
NADPH | - |
Canis lupus familiaris | |
NADPH | - |
Felis catus |