General Stability | Organism |
---|---|
2-mercaptoethanol, 1 mM, stabilizes | Saccharomyces cerevisiae |
high salt concentration stabilizes | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetate | not | Saccharomyces cerevisiae | |
p-hydroxymercuribenzoate | NAD+ protects | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.44 | - |
2-oxoglutarate | - |
Saccharomyces cerevisiae | |
0.46 | - |
NADH | - |
Saccharomyces cerevisiae | |
12 | - |
L-lysine | - |
Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
49000 | - |
sucrose density gradient centrifugation | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | Saccharomyces cerevisiae | involved in lysine biosynthesis | L-lysine + 2-oxoglutarate + NADH | - |
? | |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | Saccharomyces cerevisiae | last step of alpha-aminoadipate pathway for lysine biosynthesis | L-lysine + 2-oxoglutarate + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
baker's yeast | - |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | high specificity with respect to coenzyme and substrate | Saccharomyces cerevisiae | L-lysine + 2-oxoglutarate + NADH | - |
r | |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | i.e. saccharopine | Saccharomyces cerevisiae | L-lysine + 2-oxoglutarate + NADH | - |
r | |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | involved in lysine biosynthesis | Saccharomyces cerevisiae | L-lysine + 2-oxoglutarate + NADH | - |
? | |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | last step of alpha-aminoadipate pathway for lysine biosynthesis | Saccharomyces cerevisiae | L-lysine + 2-oxoglutarate + NADH | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
18.8 | - |
NADH | - |
Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
L-lysine + 2-oxoglutarate + NADH | Saccharomyces cerevisiae |
10 | - |
or higher, saccharopine + NAD+ + H2O | Saccharomyces cerevisiae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.2 | 9 | half-maximal activities at pH 5.2 and 9.0, L-lysine + 2-oxoglutarate + NADH | Saccharomyces cerevisiae |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | 8 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Saccharomyces cerevisiae |