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Literature summary for 1.5.1.5 extracted from

  • Paukert, J.L.; D'Ari Straus, L.; Rabinowitz, J.C.
    Formyl-methyl-methylenetetrahydrofolate synthetase-(combined). An ovine protein with multiple catalytic activities (1976), J. Biol. Chem., 251, 5104-5111.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
NADP+
-
Ovis aries
0.039
-
5,10-methylenetetrahydrofolate
-
Ovis aries

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
108000
-
2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE Ovis aries
218000
-
2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE Ovis aries
228000
-
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + NADP+ Ovis aries
-
5,10-methenyltetrahydrofolate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + NADP+
-
Ovis aries 5,10-methenyltetrahydrofolate + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE Ovis aries

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Ovis aries