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Literature summary for 1.5.1.48 extracted from

  • Mitsukura, K.; Suzuki, M.; Tada, K.; Yoshida, T.; Nagasawa, T.
    Asymmetric synthesis of chiral cyclic amine from cyclic imine by bacterial whole-cell catalyst of enantioselective imine reductase (2010), Org. Biomol. Chem., 8, 4533-4535.
    View publication on PubMed
Search for more literature for 1.5.1.48

Activating Compound

Activating Compound Comment Organism Structure
L-Glucose 130% activity in the presence of 2% (w/v) L-glucose Streptomyces sp.
additional information not activated by glycerol, sorbitol, or 2-propanal Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methyl-1-pyrroline + NADPH + H+ Streptomyces sp.
-
 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 30 mM 2-methyl-1-pyrroline at 92.3% conversion in the presence of 2% (w/v) L-glucose after 72 h incubation ?
2-methyl-1-pyrroline + NADPH + H+ Streptomyces sp.
-
 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 91 mM (R)-2-methylpyrrolidine with 99.2% e.e. and 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 100 mM 2-methyl-1-pyrroline at 91–92% conversion in the presence of 2% (w/v) L-glucose, respectively, after 84 h incubation ?
2-methyl-1-pyrroline + NADPH + H+ Streptomyces sp. 3546
-
 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 30 mM 2-methyl-1-pyrroline at 92.3% conversion in the presence of 2% (w/v) L-glucose after 72 h incubation ?
2-methyl-1-pyrroline + NADPH + H+ Streptomyces sp. 3546
-
 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 91 mM (R)-2-methylpyrrolidine with 99.2% e.e. and 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 100 mM 2-methyl-1-pyrroline at 91–92% conversion in the presence of 2% (w/v) L-glucose, respectively, after 84 h incubation ?

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
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-
-
Streptomyces sp. 3546
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-1-pyrroline + NADPH + H+
-
 Streptomyces sp. (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 30 mM 2-methyl-1-pyrroline at 92.3% conversion in the presence of 2% (w/v) L-glucose after 72 h incubation ?
2-methyl-1-pyrroline + NADPH + H+
-
 Streptomyces sp. (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 91 mM (R)-2-methylpyrrolidine with 99.2% e.e. and 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 100 mM 2-methyl-1-pyrroline at 91–92% conversion in the presence of 2% (w/v) L-glucose, respectively, after 84 h incubation ?
2-methyl-1-pyrroline + NADPH + H+
-
 Streptomyces sp. 3546 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 30 mM 2-methyl-1-pyrroline at 92.3% conversion in the presence of 2% (w/v) L-glucose after 72 h incubation ?
2-methyl-1-pyrroline + NADPH + H+
-
 Streptomyces sp. 3546 (R)-2-methylpyrrolidine + (S)-2-methylpyrrolidine + NADP+ the enzyme produces 91 mM (R)-2-methylpyrrolidine with 99.2% e.e. and 27.5 mM (S)-2-methylpyrrolidine (92.3% e.e.) from 100 mM 2-methyl-1-pyrroline at 91–92% conversion in the presence of 2% (w/v) L-glucose, respectively, after 84 h incubation ?