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Literature summary for 1.5.1.43 extracted from

  • Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A.; Michael, A.J.
    An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae (2009), J. Biol. Chem., 284, 9899-9907.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Vibrio cholerae serotype O1

Organism

Organism UniProt Comment Textmining
Vibrio cholerae serotype O1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carboxynorspermidine + H2O + NADP+
-
Vibrio cholerae serotype O1 L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
-
?
carboxynorspermidine + H2O + NADP+
-
Vibrio cholerae serotype O1 El Tor L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
-
?
carboxyspermidine + H2O + NADP+
-
Vibrio cholerae serotype O1 L-aspartate 4-semialdehyde + putrescine + NADPH + H+
-
?
carboxyspermidine + H2O + NADP+
-
Vibrio cholerae serotype O1 El Tor L-aspartate 4-semialdehyde + putrescine + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
CANSDH
-
Vibrio cholerae serotype O1
carboxynorspermidine dehydrogenase
-
Vibrio cholerae serotype O1
VC1624
-
Vibrio cholerae serotype O1

General Information

General Information Comment Organism
malfunction deletion of the enzyme leads to a 50-60% reduction in growth rate of planktonic cells and severely reduced biofilm formation Vibrio cholerae serotype O1