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Literature summary for 1.5.1.34 extracted from

  • Craine, J.E.; Hall, E.S.; Kaufman, S.
    The isolation and characterization of dihydropteridine reductase from sheep liver (1972), J. Biol. Chem., 247, 6082-6091.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
methotrexate
-
Ovis aries

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
tetrahydrobiopterin cofactor NADPH Ovis aries
0.001
-
tetrahydrobiopterin cofactor NADH Ovis aries
0.0011
-
tetrahydrobiopterin
-
Homo sapiens
0.0011
-
tetrahydrobiopterin
-
Rattus norvegicus
0.0022
-
NADH
-
Rattus norvegicus
0.004
-
NADH substrate tetrahydrobiopterin Ovis aries
0.0057
-
NADH substrate 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin Ovis aries
0.0063
-
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin cofactor NADPH Ovis aries
0.008
-
NADH
-
Homo sapiens
0.0152
-
6,7-dimethyl-5,6,7,8-tetrahydrobiopterin cofactor NADH Ovis aries
0.0709
-
NADPH substrate tetrahydrobiopterin Ovis aries
0.0806
-
NADPH substrate 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin Ovis aries
0.1
-
NADPH
-
Rattus norvegicus
0.11
-
NADPH
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
2 * 21000, liver, SDS-PAGE Ovis aries
41000
-
gradient PAGE Ovis aries

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus
-
Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
Ovis aries
-
brain
-
Homo sapiens
-
brain
-
Ovis aries
-
kidney
-
Ovis aries
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Ovis aries
-
spleen
-
Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.51
-
-
Homo sapiens
3.64
-
-
Rattus norvegicus
15.6
-
-
Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,7-dihydropteridine + NADH
-
Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
?
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
-
Ovis aries 6,7-dimethyl-7,8-dihydropterin + NADH + H+
-
r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
-
Ovis aries 6,7-dimethyl-7,8-dihydropterin + NADPH + H+
-
r
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
-
Ovis aries 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H enzyme prefers NADH Ovis aries 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
?

Subunits

Subunits Comment Organism
dimer
-
Homo sapiens
dimer
-
Rattus norvegicus
dimer 2 * 21000, liver, SDS-PAGE Ovis aries

Cofactor

Cofactor Comment Organism Structure
NADH utilizes both NADH and NADPH Homo sapiens
NADH utilizes both NADH and NADPH Rattus norvegicus
NADH utilizes both NADH and NADPH Ovis aries
NADH enzyme prefers NADH Homo sapiens
NADH enzyme prefers NADH Rattus norvegicus
NADH enzyme prefers NADH Ovis aries
NADPH utilizes both NADH and NADPH Homo sapiens
NADPH utilizes both NADH and NADPH Rattus norvegicus
NADPH utilizes both NADH and NADPH Ovis aries
NADPH NADH is preferred Homo sapiens
NADPH NADH is preferred Rattus norvegicus
NADPH NADH is preferred Ovis aries

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.038
-
methotrexate
-
Ovis aries