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Literature summary for 1.5.1.34 extracted from
- The time-dependent inactivation of human brain dihydropteridine reductase by the oxidation products of L-dopa (1986), Eur. J. Biochem., 155, 305-310.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dopachrome | 0.6 mM, 50% inhibition | Homo sapiens |  |
| L-beta-3,4-dihydroxyphenylalanine | 0.8 mM, 50% inhibition after 3 h, 80% inhibition after 16 h due to oxidation of L-DOPA to dopachrome which inhibits the enzyme | Homo sapiens | |
| additional information | quinone products of L-DOPA oxidation are responsible for the time-dependent inactivation of the enzyme | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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