Literature summary for 1.5.1.34 extracted from

Gould, K.G.; Engel, P.C.
Rat liver dihydropteridine reductase inhibition (1980), Biochem. Soc. Trans., 8, 565-566.

Search for more literature for 1.5.1.34

Inhibitors

Inhibitors	Comment	Organism	Structure
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol	-	Rattus norvegicus
noradrenaline	-	Rattus norvegicus
phenylalanine	-	Rattus norvegicus
Phenyllactate	-	Rattus norvegicus
phenylpyruvate	-	Rattus norvegicus
serotonin	-	Rattus norvegicus
tryptophan	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.012	-	6,7-dimethyl-5,6,7,8-tetrahydropterin	-	Rattus norvegicus
0.032	-	NADH	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+	-	Rattus norvegicus	quinonoid 6,7-dimethyl dihydropteridine + NADH + H+	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.05	-	phenylpyruvate	mixed inhibition	Rattus norvegicus
0.2	-	tryptophan	mixed inhibition	Rattus norvegicus
0.49	-	noradrenaline	noncompetitive inhibition	Rattus norvegicus
1	-	phenylalanine	mixed inhibition	Rattus norvegicus
1	-	Phenyllactate	mixed inhibition	Rattus norvegicus
1.2	-	serotonin	competitive inhibition	Rattus norvegicus

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Release 2023.1 (January 2023)