Crystallization (Comment) | Organism |
---|---|
in complex with NADPH, and with NADPH and biopterin, 5,6-dihydrobiopterin, or 5,6,7,8-tetrahydrobiopterin as well as in complex with NADPH and inhibitors CB3717 or trimethoprim. Enzyme does not undergo major conformational changes to accomplish binding and processing of substrates. Quinazoline moiety of inhibotr CB3717 binds similarly to pterin of substrate | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CB3717 | - |
Leishmania major | |
trimethoprim | - |
Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |