Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.33 extracted from

  • Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
    PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major (1994), Proc. Natl. Acad. Sci. USA, 91, 11442-11446.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.33

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
additional information
-
 Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania major primary enzyme mediating pteridine salvage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Biopterin + NADPH activity with NADH is less than 5% of the activity with NADPH Leishmania major 5,6,7,8-Tetrahydrobiopterin + NADP+
-
 ?
Dihydrobiopterin + NADPH
-
 Leishmania major ?
-
 ?
Dihydrofolate + NADPH
-
 Leishmania major 5,6,7,8-Tetrahydrofolate + NADP+
-
 ?
folate + NADPH
-
 Leishmania major 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
additional information no activity with quinoid dihydrobiopterin Leishmania major ?
-
 ?
additional information primary enzyme mediating pteridine salvage Leishmania major ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.7
-
 biopterin as substrate Leishmania major
4.7
-
 dihydrobiopterin as substrate Leishmania major
6
-
 dihydrofolate as substrate Leishmania major
6
-
 folate as substrate Leishmania major

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Leishmania major