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Literature summary for 1.5.1.3 extracted from

  • Miyashita, Y.; Ohmae, E.; Nakasone, K.; Katayanagi, K.
    Effects of salt on the structure, stability, and function of a halophilic dihydrofolate reductase from a hyperhalophilic archaeon, Haloarcula japonica strain TR-1 (2015), Extremophiles, 19, 479-493.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Haloarcula japonica

General Stability

General Stability Organism
addition of NaCl (0–500 mM concentration) induces significant structural formation to the enzyme. Protein stability increases depending on NaCl concentration regardless of structural formation, and HjDHFR P1 achieves the same stability as the Escherichia coli enzyme at 750 mM NaCl Haloarcula japonica

Organism

Organism UniProt Comment Textmining
Haloarcula japonica AB986558
-
-
Haloarcula japonica TR-1 AB986558
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Haloarcula japonica

Synonyms

Synonyms Comment Organism
folA3
-
Haloarcula japonica
HjDHFR
-
Haloarcula japonica

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
68
-
lowering the pH from 8 to 6 induces significant structural formation to the enzyme Haloarcula japonica

Cofactor

Cofactor Comment Organism Structure
NADPH induces significant structural formation to the enzyme Haloarcula japonica