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Literature summary for 1.5.1.3 extracted from
- Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish (2011), Acta Biochim. Biophys. Sin., 43, 957-969.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | Q6IQS4 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Danio rerio | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHFR | - |
Danio rerio |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme knockdown results in the abnormal developments of zebrafish embryos in the early stages. Obvious malformations in heart and outflow tract are also observed in knockdown embryos. Enzyme knockdown causes reduced cell proliferation and increased apoptosis | Danio rerio |
| physiological function | dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish. Enzyme overexpression promotes cell proliferation and inhibited apoptosis | Danio rerio |
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Release 2023.1 (January 2023)
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