Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Mycobacterium avium | |
2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | - |
Mycobacterium avium | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | - |
Pneumocystis carinii | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | - |
Rattus norvegicus | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium avium | - |
- |
- |
Pneumocystis carinii | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Mycobacterium avium | - |
liver | - |
Toxoplasma gondii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrofolate + NADPH + H+ | - |
Rattus norvegicus | tetrahydrofolate + NADP+ | - |
? | |
dihydrofolate + NADPH + H+ | - |
Mycobacterium avium | tetrahydrofolate + NADP+ | - |
? | |
dihydrofolate + NADPH + H+ | - |
Pneumocystis carinii | tetrahydrofolate + NADP+ | - |
? | |
dihydrofolate + NADPH + H+ | - |
Toxoplasma gondii | tetrahydrofolate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Rattus norvegicus |
DHFR | - |
Mycobacterium avium |
DHFR | - |
Pneumocystis carinii |
DHFR | - |
Toxoplasma gondii |
dihydrofolate reductase | - |
Rattus norvegicus |
dihydrofolate reductase | - |
Mycobacterium avium |
dihydrofolate reductase | - |
Pneumocystis carinii |
dihydrofolate reductase | - |
Toxoplasma gondii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Mycobacterium avium |
37 | - |
assay at | Pneumocystis carinii |
37 | - |
assay at | Toxoplasma gondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Mycobacterium avium | |
NADPH | - |
Pneumocystis carinii | |
NADPH | - |
Toxoplasma gondii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000973 | - |
37°C, pH not specified in the publication | Mycobacterium avium | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | |
0.000078 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | |
0.0086 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | |
0.012 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | |
0.012 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | |
0.012 | - |
37°C, pH not specified in the publication, value above | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | |
0.012 | - |
37°C, pH not specified in the publication, value above | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine | |
0.0144 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.016 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.016 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.019 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.02 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.02 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.0205 | - |
37°C, pH not specified in the publication | Rattus norvegicus | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid | |
0.023 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.023 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.024 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.024 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.025 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.025 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.025 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.028 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.031 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.031 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.0347 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.036 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.036 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.038 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.039 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.042 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.044 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.045 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.051 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.051 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.055 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.056 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.06 | - |
37°C, pH not specified in the publication | Pneumocystis carinii | 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.061 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.061 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.066 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.069 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.081 | - |
37°C, pH not specified in the publication | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.083 | - |
37°C, pH not specified in the publication, value above | Rattus norvegicus | 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | |
0.083 | - |
37°C, pH not specified in the publication, value above | Toxoplasma gondii | 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine | |
0.196 | - |
37°C, pH not specified in the publication | Rattus norvegicus | 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine | |
0.196 | - |
37°C, pH not specified in the publication | Mycobacterium avium | 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine |