Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | - |
Escherichia coli | |
2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | - |
Homo sapiens | |
2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
methotrexate | - |
Escherichia coli | |
methotrexate | - |
Homo sapiens | |
methotrexate | - |
Toxoplasma gondii | |
additional information | inhibitor synthesis and molecular modelling | Escherichia coli | |
additional information | inhibitor synthesis and molecular modelling | Homo sapiens | |
additional information | inhibitor synthesis and molecular modelling | Toxoplasma gondii | |
N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | binding mode, overview | Escherichia coli | |
N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | binding mode, overview | Homo sapiens | |
N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | binding mode, overview | Toxoplasma gondii | |
nolatrexed | - |
Escherichia coli | |
nolatrexed | - |
Homo sapiens | |
nolatrexed | - |
Toxoplasma gondii | |
pemetrexed | - |
Escherichia coli | |
pemetrexed | - |
Homo sapiens | |
pemetrexed | - |
Toxoplasma gondii | |
raltitrexed | - |
Escherichia coli | |
raltitrexed | - |
Homo sapiens | |
raltitrexed | - |
Toxoplasma gondii | |
trimethoprim | - |
Escherichia coli | |
trimethoprim | - |
Homo sapiens | |
trimethoprim | - |
Toxoplasma gondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | Escherichia coli | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | Toxoplasma gondii | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | Homo sapiens | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | P00374 | - |
- |
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH + H+ | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
Toxoplasma gondii | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHFR | - |
Escherichia coli |
DHFR | - |
Toxoplasma gondii |
DHFR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli | |
NADPH | - |
Toxoplasma gondii | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000008 | - |
- |
Toxoplasma gondii | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | |
0.0000088 | - |
- |
Escherichia coli | methotrexate | |
0.00001 | - |
- |
Escherichia coli | trimethoprim | |
0.00002 | - |
- |
Homo sapiens | methotrexate | |
0.00002 | - |
- |
Homo sapiens | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | |
0.000031 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.000033 | - |
- |
Toxoplasma gondii | methotrexate | |
0.000034 | - |
- |
Toxoplasma gondii | 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.000038 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.000044 | - |
- |
Toxoplasma gondii | 2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.000048 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.000056 | - |
- |
Toxoplasma gondii | 2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.000056 | - |
- |
Toxoplasma gondii | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.000064 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.00012 | - |
- |
Toxoplasma gondii | 2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | |
0.0002 | - |
- |
Escherichia coli | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl)-L-glutamic acid | |
0.00043 | - |
- |
Toxoplasma gondii | permetrexed | |
0.00056 | - |
- |
Homo sapiens | 2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0012 | - |
- |
Escherichia coli | 2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0015 | - |
- |
Homo sapiens | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0025 | - |
- |
Homo sapiens | 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0026 | - |
- |
Homo sapiens | 2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0028 | - |
- |
Escherichia coli | 2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0028 | - |
- |
Homo sapiens | 2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0028 | - |
- |
Escherichia coli | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0029 | - |
- |
Homo sapiens | 2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.0035 | - |
- |
Homo sapiens | 2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | |
0.0056 | - |
- |
Homo sapiens | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.0066 | - |
- |
Homo sapiens | permetrexed | |
0.0068 | - |
- |
Toxoplasma gondii | trimethoprim | |
0.022 | - |
- |
Homo sapiens | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.028 | - |
- |
Escherichia coli | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.028 | - |
- |
Escherichia coli | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.032 | - |
- |
Escherichia coli | 2-amino-5-[(4-fluorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one | |
0.035 | - |
- |
Escherichia coli | 2-amino-4-oxo-6-methyl-5-phenylsulfanylthieno[2,3-d]pyrimidine | |
0.035 | - |
- |
Escherichia coli | 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.058 | - |
- |
Escherichia coli | 2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
0.23 | - |
- |
Escherichia coli | permetrexed | |
0.34 | - |
- |
Homo sapiens | trimethoprim |