Application | Comment | Organism |
---|---|---|
medicine | the naturally occurring single nucleotide polymorhism C829T, near the miR-24 binding site in the 3' UTR of human dihydrofolate reductase leads to a decrease in microRNA binding, which in turn leads to overexpression of its target and results in resistance to methotrexate | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C829T | naturally occurring single nucleotide polymorhism , near the miR-24 binding site in the 3' UTR of human dihydrofolate reductase leads to a decrease in microRNA binding, which in turn leads to overexpression of its target and results in resistance to methotrexate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |