Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-5-isopropyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | evaluation of cytotoxicity against 17 different tumor cell lines | Homo sapiens | |
2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
2,4-diamino-5-propyl-6-(1'-naphthylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine | - |
Toxoplasma gondii | |
2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | evaluation of cytotoxicity against 17 different tumor cell lines. GI values are below 100 nM | Homo sapiens | |
2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | - |
Pneumocystis carinii | |
2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | - |
Rattus norvegicus | |
methotrexate | - |
Toxoplasma gondii | |
pemetrexed | - |
Toxoplasma gondii | |
pyrimethamine | - |
Toxoplasma gondii | |
trimetrexate | - |
Pneumocystis carinii | |
trimetrexate | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00374 | - |
- |
Pneumocystis carinii | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | evaluation of cytotoxicity of compounds 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine and 2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine against 17 different tumor cell lines. GI values of compound 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine are below 100 nM | Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Toxoplasma gondii | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
37°C | Rattus norvegicus | trimetrexate | |
0.00000311 | - |
37°C | Pneumocystis carinii | 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | |
0.0000048 | - |
37°C | Pneumocystis carinii | 2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | |
0.000011 | - |
37°C | Toxoplasma gondii | methotrexate | |
0.000042 | - |
37°C | Pneumocystis carinii | trimetrexate | |
0.000058 | - |
37°C | Toxoplasma gondii | 2,4-diamino-5-propyl-6-(1'-naphthylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine | |
0.00006 | - |
37°C | Rattus norvegicus | 2,4-diamino-5-propyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | |
0.000064 | - |
37°C | Toxoplasma gondii | 2,4-diamino-5-isopropyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine | |
0.00008 | - |
37°C | Toxoplasma gondii | pyrimethamine | |
0.000186 | - |
37°C | Rattus norvegicus | 2,4-diamino-5-isopropyl-6-arylthio-7H-pyrrolo[2,3-d]pyrimidine | |
0.00046 | - |
37°C | Toxoplasma gondii | pemetrexed |