Literature summary for 1.5.1.3 extracted from

ONeil, M.T.; Korsinczky, M.L.; Gresty, K.J.; Auliff, A.; Cheng, Q.
A novel Plasmodium falciparum expression system for assessing antifolate resistance caused by mutant P. vivax dihydrofolate reductase-thymidylate synthase (2007), J. Infect. Dis., 196, 467-474.

Search for more literature for 1.5.1.3

Application

Application	Comment	Organism
drug development	expression of bifunctional dihydrofolate reductase-thymidylate synthase in plasmodium falciparum to assess interaction with antifolates	Plasmodium vivax

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of mutant AMRU1, i.e. 57L/58R/61M/1117T, in Plasmodium falciparum provides significant protection against pyrimethamine, cycloguanil, and clociguanil. It confers greater resistance to cycloguanil, clociguanil, and WR99210 than the homologous Plasmodium falciparum mutant	Plasmodium vivax

Inhibitors

Inhibitors	Comment	Organism	Structure
clociguanil	-	Plasmodium vivax
cycloguanil	-	Plasmodium vivax
pyrimethamine	-	Plasmodium vivax
WR99210	-	Plasmodium vivax

Organism

Organism	UniProt	Comment	Textmining
Plasmodium vivax	Q00NX3	fragment; bifunctional dihydrofolate reductase-thymidylate synthase	-

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Release 2023.1 (January 2023)