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BRENDA support

Literature summary for 1.5.1.3 extracted from

  • Bowman, A.L.; Lerner, M.G.; Carlson, H.A.
    Protein flexibility and species specificity in structure-based drug discovery: dihydrofolate reductase as a test system (2007), J. Am. Chem. Soc., 129, 3634-3640.
    View publication on PubMed

Application

Application Comment Organism
analysis use of multiple protein structure technique for structure-based drug discovery. Construction of receptor-based pharmacophores using multiple X-ray crystallographic structures. Models incorporate a fair degree of protein flexibility and are highly selective for known inhibitors over drug-like non-inhibitors Homo sapiens
analysis use of multiple protein structure technique for structure-based drug discovery. Construction of receptor-based pharmacophores using multiple X-ray crystallographic structures. Models incorporate a fair degree of protein flexibility and are highly selective for known inhibitors over drug-like non-inhibitors Pneumocystis carinii
drug development use of multiple protein structure technique for structure-based drug discovery. Construction of receptor-based pharmacophores using multiple X-ray crystallographic structures. Models incorporate a fair degree of protein flexibility and are highly selective for known inhibitors over drug-like non-inhibitors Homo sapiens
drug development use of multiple protein structure technique for structure-based drug discovery. Construction of receptor-based pharmacophores using multiple X-ray crystallographic structures. Models incorporate a fair degree of protein flexibility and are highly selective for known inhibitors over drug-like non-inhibitors Pneumocystis carinii

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Pneumocystis carinii
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