Literature summary for 1.5.1.3 extracted from

Tanomsing, N.; Imwong, M.; Pukrittayakamee, S.; Chotivanich, K.; Looareesuwan, S.; Mayxay, M.; Dolecek, C.; Hien, T.T.; do Rosario, V.E.; Arez, A.P.; Michon, P.; Snounou, G.; White, N.J.; Day, N.P.
Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae (2007), Antimicrob. Agents Chemother., 51, 3523-3530.

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Protein Variants

Protein Variants	Comment	Organism
additional information	survey of polymorphisms in 35 isolates of Plasmodium malariae collected from five countries in Asia and Africa reveals a low copy number of nonsynonymous mutations in five codons	Plasmodium malariae

Inhibitors

Inhibitors	Comment	Organism	Structure
Chloroquine	mean 50% inhibitory concentration 74.94 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa	Plasmodium malariae
pyrimethamine	mean 50% inhibitory concentration 2.24 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa	Plasmodium malariae

Organism

Organism	UniProt	Comment	Textmining
Plasmodium malariae	-	bifunctional dihydrofolate reductase/thymidylate synthase	-

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Release 2023.1 (January 2023)