Crystallization (Comment) | Organism |
---|---|
wild-type and pyrimethamine-resistant mutant S58R/S117N in complex with NADPH and inhibitors pyrimethamine or 6-ethyl-5-phenylpyrimidine-2,4-diamine | Plasmodium vivax |
Protein Variants | Comment | Organism |
---|---|---|
S58R/S117N | pyrimethamine-resistant mutant | Plasmodium vivax |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-ethyl-5-phenylpyrimidine-2,4-diamine | analogue of pyrimethamine lacking the 4-Cl group, effectively inhibits both wild-type and pyrimethamine-resistant mutant S58R/S117N | Plasmodium vivax | |
pyrimethamine | - |
Plasmodium vivax |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium vivax | O02604 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000016 | - |
pyrimethamine | wild-type | Plasmodium vivax | |
0.00000155 | - |
6-ethyl-5-phenylpyrimidine-2,4-diamine | wild-type | Plasmodium vivax | |
0.00000733 | - |
6-ethyl-5-phenylpyrimidine-2,4-diamine | mutant S58R/S117N | Plasmodium vivax | |
0.00005 | - |
pyrimethamine | mutant S58R/S117N | Plasmodium vivax |