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Literature summary for 1.5.1.3 extracted from

  • Al-Rashood, S.T.; Aboldahab, I.A.; Nagi, M.N.; Abouzeid, L.A.; Abdel-Aziz, A.A.; Abdel-Hamide, S.G.; Youssef, K.M.; Al-Obaid, A.M.; El-Subbagh, H.I.
    Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs (2006), Bioorg. Med. Chem., 14, 8608-8621.
    View publication on PubMed
Search for more literature for 1.5.1.3

Inhibitors

Inhibitors Comment Organism Structure
3-benzyl-6-[(3,4-dimethoxybenzyl)(methyl)amino]-2-(methylsulfanyl)quinazolin-4(3H)-one 50% inhibition at 0.001 mM Bos taurus
3-benzyl-6-[(4-methoxybenzyl)(methyl)amino]-2-(methylsulfanyl)quinazolin-4(3H)-one 50% inhibition at 0.0005 mM Bos taurus
4-benzyl-N-[3-benzyl-2-(methylsulfanyl)-4-oxo-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.008 mM Bos taurus
4-bromo-N-[2-(methylthio)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.002 mM Bos taurus
6-([(1E)-(4-methoxyphenyl)methylene]amino)-2-(methylthio)-3-phenylquinazolin-4(3H)-one 50% inhibition at 0.002 mM Bos taurus
6-[(4-methoxybenzyl)(methyl)amino]-2-(methylsulfanyl)-3-phenylquinazolin-4(3H)-one 50% inhibition at 0.001 mM Bos taurus
N-[2-(methylsulfanyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]biphenyl-4-sulfonamide 50% inhibition at 0.005 mM Bos taurus
N-[2-(methylthio)-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 50% inhibition at 0.002 mM Bos taurus
N-[3-benzyl-2-(methylsulfanyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-4-methylbenzenesulfonamide 50% inhibition at 0.007 mM Bos taurus
N-[3-benzyl-2-(methylthio)-4-oxo-3,4-dihydroquinazolin-6-yl]-4-bromobenzenesulfonamide 50% inhibition at 0.005 mM Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Bos taurus
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