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Literature summary for 1.5.1.3 extracted from

  • Joska, T.M.; Anderson, A.C.
    Structure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leads (2006), Antimicrob. Agents Chemother., 50, 3435-3443.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development enzyme is identical to enzyme from Bacillus anthracis. Use of enzyme as antimicrobial target for Bacillus anthracis, homology modelling of inhibitors and growth inhibition assays Bacillus cereus
drug development enzyme is identical to enzyme from Bacillus cereus. Use of enzyme from Bacillus cereus as antimicrobial target for Bacillus anthracis, homology modelling of inhibitors and growth inhibition assays Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
4-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]butanoic acid 50% inhibition of growth in culture at 0.00060 mM Bacillus cereus
5-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]pentanoic acid 50% inhibition of growth in culture at 0.00167 mM Bacillus cereus
6-([(2-bromo-3,4,5-trimethoxyphenyl)amino]methyl)quinazoline-2,4-diamine 50% inhibition of growth in culture at 0.0011 mM Bacillus cereus
6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]hexanoic acid 50% inhibition of growth in culture at 0.00051 mM Bacillus cereus
6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl]hex-5-ynoic acid 50% inhibition of growth in culture at 0.00190 mM Bacillus cereus
7-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl]hept-6-ynoic acid 50% inhibition of growth in culture at 0.000027 mM Bacillus cereus
ethyl 4-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]butanoate 50% inhibition of growth in culture at 0.00088 mM Bacillus cereus
ethyl 5-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]pentanoate 50% inhibition of growth in culture at 0.00035 mM Bacillus cereus
ethyl 6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy]hexanoate 50% inhibition of growth in culture at 0.00185 mM Bacillus cereus
N-[(4-[[(2,4-diaminopteridin-6-yl)methyl](methyl)amino]phenyl)carbonyl]glutamic acid 50% inhibition of growth in culture at 0.000024 mM Bacillus cereus

Organism

Organism UniProt Comment Textmining
Bacillus anthracis Q81R22
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Bacillus cereus Q81E04
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