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Literature summary for 1.5.1.3 extracted from

  • Sekiguchi, J.; Tharavichitkul, P.; Miyoshi-Akiyama, T.; Chupia, V.; Fujino, T.; Araake, M.; Irie, A.; Morita, K.; Kuratsuji, T.; Kirikae, T.
    Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454) (2005), Antimicrob. Agents Chemother., 49, 3948-3951.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.3

Cloned(Commentary)

Cloned (Comment) Organism
-
 Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
trimethoprim 50% inhibition at 0.254 mM Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00238
-
 NADPH
-
 Staphylococcus aureus
0.00268
-
 7,8-dihydrofolate
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
 trimethoprim-resistant enzyme
-
Staphylococcus aureus CM.S2
-
 trimethoprim-resistant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH
-
 Staphylococcus aureus 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
7,8-dihydrofolate + NADPH
-
 Staphylococcus aureus CM.S2 5,6,7,8-tetrahydrofolate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
S3DHFR
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Staphylococcus aureus