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Literature summary for 1.5.1.3 extracted from

  • Djaman, J.A.; Mazabraud, A.; Basco, L.
    Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire (2007), Ann. Trop. Med. Parasitol., 101, 103-112.
    View publication on PubMed

Application

Application Comment Organism
medicine study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reductase is associated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
additional information study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reductase is associated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
pyrimethamine study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reducatase is assovciated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
isolates from Cote d'Ivoire
-