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Literature summary for 1.5.1.20 extracted from

  • Yuan, R.Y.; Sheu, J.J.; Yu, J.M.; Hu, C.J.; Tseng, I.J.; Ho, C.S.; Yeh, C.Y.; Hung, Y.L.; Chiang, T.R.
    Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinsons disease patients (2009), J. Neurol. Sci., 287, 64-68.
    View publication on PubMed

Application

Application Comment Organism
medicine in Parkinson patients, plasma homocysteine elevation may be caused by levodopa administration, and further promoted by MTHFR C677T heterozygotes and homozygote C677T/C677T, but not by A1298C genotypes. The promoting elevation in 1298A homozygotes is attributed to combining the 677T allele. Neither C677T nor A1298C genotypes contribute to elevating plasma homocysteine in Parkinson patients without levodopa treatment Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with Parkinson's disease
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