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Literature summary for 1.5.1.20 extracted from

  • Pickell, L.; Li, D.; Brown, K.; Mikael, L.G.; Wang, X.L.; Wu, Q.; Luo, L.; Jerome-Majewska, L.; Rozen, R.
    Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice (2009), Birth Defects Res. Part A Clin. Mol. Teratol., 85, 531-541.
    View publication on PubMed

Application

Application Comment Organism
medicine maternal MTHFR and dietary folate deficiencies in Mthfr +/- mice result in increased developmental delays and smaller embryos. Folate-deficient mice also have increased embryonic losses and severe placental defects, including placental abruption and disturbed patterning of placental layers. Folate-deficient placentae have decreased ApoA-I expression, and there is a trend toward a negative correlation between ApoA-I expression with maternal homocysteine concentrations Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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mouse model of mild Mthfr deficiency
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