Literature summary for 1.5.1.20 extracted from

Celtikci, B.; Leclerc, D.; Lawrance, A.K.; Deng, L.; Friedman, H.C.; Krupenko, N.I.; Krupenko, S.A.; Melnyk, S.; James, S.J.; Peterson, A.C.; Rozen, R.
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice (2008), Pharmacogenet. Genomics, 18, 577-589.

Search for more literature for 1.5.1.20

Application

Application	Comment	Organism
medicine	MTHFR deficiency in mice is accompanied with hyperhomocysteinemia and decreased hematocrit, hemoglobin, and red blood cell numbers, increased nephrotoxicity und hepatotoxicity compared to wild type animals	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + reduced acceptor	-	Mus musculus	5-methyltetrahydrofolate + oxidized acceptor	-	ir

Synonyms

Synonyms	Comment	Organism
methylenetetrahydrofolate reductase	-	Mus musculus
MTHFR	-	Mus musculus

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Release 2023.1 (January 2023)