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Literature summary for 1.5.1.20 extracted from
- Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency (2008), J. Cell. Biochem., 105, 467-476.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Valproic acid | 300 mg/kg treatment increases MTHFR promoter activity 2.5fold and MTHFR mRNA and protein 3.7fold | Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HepG2 cells | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + reduced acceptor | - |
Mus musculus | 5-methyltetrahydrofolate + oxidized acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate reductase | - |
Mus musculus |
| MTHFR | - |
Mus musculus |
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Release 2023.1 (January 2023)
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