Any feedback?
Literature summary for 1.5.1.20 extracted from
- Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer (2008), J. Biol. Chem., 283, 3151-3160.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| A23187 | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus |  |
| homocysteine | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
| inositol-requiring enzyme-1 | the induction of MTHFR was also observed after overexpression of inositol-requiring enzyme-1 | Mus musculus | |
| additional information | transfection of c-Jun and two activators of c-Jun (LiCl and sodium valproate) increase MTHFR expression, MTHFR mRNA is up-regulated by endoplasmic reticulum stress | Mus musculus | |
| additional information | induction of MTHFR is observed after overexpression of inositol-requiring enzyme IRE1 and is inhibited by a dominant-negative mutant of IRE1. Tranfection of c-Jun and its activators LiCl and sodium valproate increase MTHFR expression, whereas inhibitor of c-Jun SP600125 reduces activation | Mus musculus | |
| thapsigargin | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
| tunicamycin | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli and Neuro-2a cells | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibited by a dominant-negative mutant of inositol-requiring enzyme-1, a reported inhibitor of c-Jun (SP600125) and a dominant-negative derivative of c-Jun N-terminal kinase-1 reduce MTHFR activation | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Neuro-2a cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + reduced acceptor | - |
Mus musculus | 5-methyltetrahydrofolate + oxidized acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate reductase | - |
Mus musculus |
| MTHFR | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
