Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.20 extracted from

  • Yamada, K.; Strahler, J.R.; Andrews, P.C.; Matthews, R.G.
    Regulation of human methylenetetrahydrofolate reductase by phosphorylation (2005), Proc. Natl. Acad. Sci. USA, 102, 10454-10459.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
T34A complete blocking of phosphorylation of enzyme. Mutant enzyme is more active than wild-type and less sensitive to inhibition by S-adenosylmethionie Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-methionine allosteric inhibition and control of phosphorylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme, expression in Escherichia coli, Baculovirus system, or HEK293 cells
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein treatment by alkaline phosphatase removes seven phosphoryl groups from enzyme. Treated enzyme is more active than native enzyme and less sensitive to inhibition by S-adenosylmethionie Homo sapiens