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Literature summary for 1.5.1.20 extracted from

  • Vanoni, M.A.; Ballou, D.P.; Matthews, R.G.
    Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme (1983), J. Biol. Chem., 258, 11510-11514.
    View publication on PubMed
Search for more literature for 1.5.1.20

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 NADPH NADPH-menadione oxidoreductase reaction Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + NADPH Sus scrofa
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
homogeneity Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+ mechanism Sus scrofa
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6R,S)-5,10-methylenetetrahydrofolate + ?
-
 Sus scrofa ?
-
 ?
5,10-methylenetetrahydrofolate + NADPH ping pong bi bi mechanism Sus scrofa 5-methyltetrahydrofolate + NADP+
-
 ?
5,10-methylenetetrahydrofolate + NADPH
-
 Sus scrofa ?
-
 ?
5-methyltetrahydrofolate + oxidized menadione
-
 Sus scrofa 5,10-methylenetetrahydrofolate + reduced menadione
-
 ?
NADPH + H+ + menadione
-
 Sus scrofa NADP+ + menadiol
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
50
-
 methylenetetrahydrofolate
-
 Sus scrofa
160
-
 NADPH
-
 Sus scrofa