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Literature summary for 1.5.1.2 extracted from

  • Liu, W.; Zabirnyk, O.; Wang, H.; Shiao, Y.H.; Nickerson, M.L.; Khalil, S.; Anderson, L.M.; Perantoni, A.O.; Phang, J.M.
    miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer (2010), Oncogene, 29, 4914-4924.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine micro-RNA miR-23b*, by targeting POX, may function as an oncogene. Pairs of human renal carcinoma and normal tissues show a negative correlation between miR-23b* and POX protein expression, providing its clinical corroboration. Ectopic overexpression of miR-23b* in normal renal cells results in striking downregulation of POX, whereas POX expression increases markedly when endogenous miR-23b* is knocked down by its antagomirs in renal cancer cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HBEpC cell
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 Homo sapiens
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RCC 786-O cell
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 Homo sapiens
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renal cancer cell
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 Homo sapiens
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renal cell carcinoma cell
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 Homo sapiens
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TK-10 cell
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 Homo sapiens
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UO-31 cell
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens upregulated micro-RNA miR-23b* in renal cancer is an important regulator of POX. Ectopic overexpression of miR-23b* in normal renal cells results in striking downregulation of POX, whereas POX expression increases markedly when endogenous miR-23b* is knocked down by its antagomirs in renal cancer cells down