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Literature summary for 1.5.1.2 extracted from
- Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta 1-pyrroline-3-hydroxy-5-carboxylate (1960), J. Biol. Chem., 235, 3499-3503.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-allohydroxyproline | competitive inhibition | Bos taurus |  |
| imidazole | - |
Bos taurus | |
| L-hydroxyproline | competitive inhibition | Bos taurus | |
| proline | competitive inhibition | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.4 | - |
DELTA1-pyrroline-3-hydroxy-5-carboxylate | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, glutathione, EDTA | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H | - |
Bos taurus | L-hydroxyproline + NAD(P)+ | - |
ir | |
| 1-pyrroline-5-carboxylate + NAD(P)H + H+ | - |
Bos taurus | L-proline + NAD(P)+ | - |
ir | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Bos taurus | |
| NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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