Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.15 extracted from

  • Saffroy, R.; Pham, P.; Chiappini, F.; Gross-Goupil, M.; Castera, L.; Azoulay, D.; Barrier, A.; Samuel, D.; Debuire, B.; Lemoine, A.
    The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis (2004), Carcinogenesis, 25, 1443-1448.
    View publication on PubMed
Search for more literature for 1.5.1.15

Protein Variants

Protein Variants Comment Organism
C677T one of several polymorphisms, leads to increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis, determination of genotypes in liver transplant patients with cirrhosis with and without hepatocellular carcinoma and in healthy persons Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens key enzyme in folate metabolism playing a major role in provision of methyl groups for DNA methylation and in production of dTMP for DNA synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with alcoholic cirrhosis
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocarcinoma cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information key enzyme in folate metabolism playing a major role in provision of methyl groups for DNA methylation and in production of dTMP for DNA synthesis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate reductase
-
 Homo sapiens
More cf. EC 1.5.1.20 Homo sapiens
MTHFR
-
 Homo sapiens