Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21/(DE-3) RIL cells | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-6-heptenoic acid | competitive inhibition versus L-alpha-aminoadipate-delta-semialdehyde, uncompetitive inhibition versus NADPH, and noncompetitive inhibitition versus L-glutamate | Saccharomyces cerevisiae | |
2-oxoglutarate | competitive inhibition versus L-glutamate and uncompetitive inhibition versus L-alpha-aminoadipate-delta-semialdehyde and NADPH; competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
alpha-AASA | shows noncompetitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
glyoxylic acid | competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
L-glutamate | exhibits noncompetitive inhibition versus NADP+ and saccharopine | Saccharomyces cerevisiae | |
L-leucine | competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
L-ornithine | competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
L-pipecolic acid | competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
N-oxalylglycine | competitive inhibition versus saccharopine and uncompetitive inhibition versus NADP+ | Saccharomyces cerevisiae | |
NADP+ | competitive inhibition versus NADPH, noncompetitive inhibition versus L-alpha-aminoadipate-delta-semialdehyde and L-glutamate | Saccharomyces cerevisiae | |
NADPH | inhibition is competitive versus NADP+ and noncompetitive versus saccharopine | Saccharomyces cerevisiae | |
saccharopine | exhibits noncompetitive inhibition against L-alpha-aminoadipate-delta-semialdehyde, L-glutamate, and NADPH | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminoadipate 6-semialdehyde + L-glutamate + NADPH + H+ | - |
Saccharomyces cerevisiae | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
saccharopine dehydrogenase (L-glutamate forming) | - |
Saccharomyces cerevisiae |
saccharopine reductase | - |
Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Saccharomyces cerevisiae |