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Literature summary for 1.4.99.5 extracted from

  • Castric, P.
    Influence of oxygen on the Pseudomonas aeruginosa hydrogen cyanide synthase (1994), Curr. Microbiol., 29, 19-21.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.99.5

Activating Compound

Activating Compound Comment Organism Structure
pyocyanin secondary metabolite, supports HCS mediated cyanide production Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
O2
-
 Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + O2 Pseudomonas aeruginosa
-
 HCN + CO2 + 2 H2O
-
 ?
glycine + O2 Chromobacterium violaceum
-
 HCN + CO2 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Chromobacterium violaceum
-
-
-
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa 9-D2
-
-
-

Oxidation Stability

Oxidation Stability Organism
synthesis of HCN is repressed under highly aerobic conditions, cyanogenic enzyme system is rapidly inactivated, both in vivo and in vitro, in the presence of oxygen Pseudomonas aeruginosa

Purification (Commentary)

Purification (Comment) Organism
partially Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + 2,2'-di-(p-nitrophenyl-5,5')-(diphenyl)-3,3'-(3,3'-dimethoxy-4,4'-diphenylene) ditetrazolium chloride NBT Pseudomonas aeruginosa HCN + ?
-
 ?
glycine + 2,6-dichlorophenol-indophenol DCIP Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
glycine + 2,6-dichlorophenol-indophenol DCIP Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
glycine + 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl-tetrazolium chloride INT Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
glycine + O2
-
 Pseudomonas aeruginosa HCN + CO2 + H2O
-
 ?
glycine + O2
-
 Chromobacterium violaceum HCN + CO2 + H2O
-
 ?
glycine + O2
-
 Pseudomonas aeruginosa 9-D2 HCN + CO2 + H2O
-
 ?
glycine + O2
-
 Pseudomonas aeruginosa HCN + CO2 + 2 H2O
-
 ?
glycine + O2
-
 Chromobacterium violaceum HCN + CO2 + 2 H2O
-
 ?
glycine + phenazine methosulfate PMS provided greatest activity, oxygen allows only a limited response Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
glycine + phenazine methosulfate PMS provided greatest activity, oxygen allows only a limited response Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
glycine + potassium ferricyanide
-
 Pseudomonas aeruginosa HCN + CO2 + ?
-
 ?
glycine + potassium ferricyanide
-
 Pseudomonas aeruginosa 9-D2 HCN + CO2 + ?
-
 ?
glycine + pyocyanine
-
 Pseudomonas aeruginosa HCN + ?
-
 ?
additional information sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis Pseudomonas aeruginosa ?
-
 ?
additional information sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis Pseudomonas aeruginosa 9-D2 ?
-
 ?

Synonyms

Synonyms Comment Organism
cyanogenic enzyme system
-
 Pseudomonas aeruginosa
HCA
-
 Pseudomonas aeruginosa
HCS
-
 Pseudomonas aeruginosa