Literature summary for 1.4.9.1 extracted from

Sun, D.; Davidson, V.L.
Inter-subunit cross-linking of methylamine dehydrogenase by cyclopropylamine requires residue alphaPhe55 (2002), FEBS Lett., 517, 172-174.

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Protein Variants

Protein Variants	Comment	Organism
alphaF55A	inactivation by the mechanism-based inhibitor cyclopropylamine is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of the enzyme. No cross-linking is seen with mutant enzymes alphaF55A or alphaF55I mutant enzymes	Paracoccus denitrificans
alphaF55I	inactivation by the mechanism-based inhibitor cyclopropylamine is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of the enzyme. No cross-linking is seen with mutant enzymes alphaF55A or alphaF55I mutant enzymes	Paracoccus denitrificans

Inhibitors

Inhibitors	Comment	Organism	Structure
cyclopropylamine	mechanism-based inhibitor. The resulting inactivation is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of the enzyme. No cross-linking is seen with mutant enzymes alphaF55A or alphaF55I mutant enzymes. With mutant enzyme alphaF55E cross-linking of subunits is observed	Paracoccus denitrificans

Organism

Organism	UniProt	Comment	Textmining
Paracoccus denitrificans	-	-	-

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Release 2023.1 (January 2023)