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Literature summary for 1.4.4.2 extracted from

  • Hagemann, M.; Vinnemeier, J.; Oberpichler, I.; Boldt, R.; Bauwe, H.
    The glycine decarboxylase complex is not essential for the cyanobacterium Synechocystis sp. strain PCC 6803 (2005), Plant Biol., 7, 15-22.
    View publication on PubMed

Application

Application Comment Organism
additional information GDC is not necessary for cell viability under standard conditions. GDC is dispensable for Synechocystis Synechocystis sp.

Cloned(Commentary)

Cloned (Comment) Organism
into pGEM-T vector for DNA manipulations and sequence analysis using the Escherichia coli strain TG1 Synechocystis sp. PCC 6803

Protein Variants

Protein Variants Comment Organism
additional information mutation of the genes for GDC subunits P, T, or H protein. No changes in growth, pigmentation, or photosynthesis in the GDC subunit mutants, regardless of whether or not cultivated at ambient or high CO2 concentrations. Mutation of GDC leads to an increased glycine/serine ratio in the mutant cells. Supplementation of the medium with low glycine concentrations is toxic for the mutants but not for wild-type cells Synechocystis sp.
Mu0171 T protein mutant, from the gene sll0171, an internal 1 kb fragment is deleted and replaced by the aphll gene Synechocystis sp. PCC 6803
Mu293 P protein mutant, from the gene slr0293, an internal 2.1 kb fragment is deleted and replaced by the aphll gene Synechocystis sp. PCC 6803
Mu879 H protein mutant, from the gene slr0879, an internal 0.2 kb fragment is deleted and replaced by the aphll gene Synechocystis sp. PCC 6803

Inhibitors

Inhibitors Comment Organism Structure
additional information low CO2 concentrations decrease expression of GDC Synechocystis sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + H-protein-lipoyllysine Synechocystis sp. PCC 6803
-
H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Synechocystis sp.
-
strain PCC 6803
-
Synechocystis sp. PCC 6803
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + H-protein-lipoyllysine
-
Synechocystis sp. PCC 6803 H-protein-S-aminomethyldihydrolipoyllysine + CO2
-
?

Subunits

Subunits Comment Organism
tetramer P, T, L and H protein Synechocystis sp. PCC 6803

Synonyms

Synonyms Comment Organism
GDC
-
Synechocystis sp.
GDC
-
Synechocystis sp. PCC 6803
glycine decarboxylase
-
Synechocystis sp. PCC 6803
glycine decarboxylase complex
-
Synechocystis sp.
glycine decarboxylase complex
-
Synechocystis sp. PCC 6803
glycine dehydrogenase
-
Synechocystis sp. PCC 6803
H protein
-
Synechocystis sp.
P protein
-
Synechocystis sp.
T protein
-
Synechocystis sp.