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Literature summary for 1.4.4.2 extracted from

  • Fujiwara, K.; Motokawa, Y.
    Mechanism of the glycine cleavage reaction. Steady state kinetic studies of the P-protein-catalyzed reaction (1983), J. Biol. Chem., 258, 8156-8162.
    View publication on PubMed
Search for more literature for 1.4.4.2

Inhibitors

Inhibitors Comment Organism Structure
CO2 product inhibition Gallus gallus
Glycine methyl ester
-
 Gallus gallus
Modified H-protein lipoic acid prosthetic group and cysteinyl residues modified with N-ethylmaleimide Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
 glycine
-
 Gallus gallus
5.8
-
 glycine
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + lipoylprotein Gallus gallus lipoyl protein: H-protein, lipoamide can also act as acceptor S-aminomethyldihydrolipoylprotein + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2 mechanism Gallus gallus
a
glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2 sequential random bi bi mechanism in which no abortive dead end complex is formed Gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + lipoylprotein lipoyl protein: H-protein, lipoamide can also act as acceptor Gallus gallus S-aminomethyldihydrolipoylprotein + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
 glycine + lipoylprotein Gallus gallus