Protein Variants | Comment | Organism |
---|---|---|
R229W | the mutation is associated with lethality in neonatal epileptic encephalopathy | Homo sapiens |
R95C | the mutation is associated with lethality in neonatal epileptic encephalopathy | Homo sapiens |
R95H | the mutation is associated with lethality in neonatal epileptic encephalopathy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | competitive inhibitor | Escherichia coli | |
pyridoxal 5'-phosphate | competitive inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridoxamine 5'-phosphate + H2O + O2 | Escherichia coli | - |
pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
pyridoxamine 5'-phosphate + H2O + O2 | Homo sapiens | - |
pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
pyridoxine 5'-phosphate + H2O + O2 | Homo sapiens | - |
pyridoxal 5'-phosphate + H2O2 | - |
? | |
pyridoxine 5'-phosphate + H2O + O2 | Escherichia coli | preferred substrate | pyridoxal 5'-phosphate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridoxamine 5'-phosphate + H2O + O2 | - |
Escherichia coli | pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
pyridoxamine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + NH3 + H2O2 | - |
? | |
pyridoxine 5'-phosphate + H2O + O2 | - |
Homo sapiens | pyridoxal 5'-phosphate + H2O2 | - |
? | |
pyridoxine 5'-phosphate + H2O + O2 | preferred substrate | Escherichia coli | pyridoxal 5'-phosphate + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Escherichia coli |
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PNP oxidase | - |
Escherichia coli |
PNP oxidase | - |
Homo sapiens |
PNPOx | - |
Escherichia coli |
PNPOx | - |
Homo sapiens |
pyridoxine (pyridoxamine) 5'-phosphate oxidase | - |
Escherichia coli |
pyridoxine (pyridoxamine) 5'-phosphate oxidase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | dependent on | Escherichia coli | |
FMN | dependent on | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
pyridoxal 5'-phosphate | pH and temperature not specified in the publication | Homo sapiens | |
0.008 | - |
pyridoxal 5'-phosphate | pH and temperature not specified in the publication | Escherichia coli |