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Literature summary for 1.4.3.5 extracted from

  • di Salvo, M.L.; Contestabile, R.; Safo, M.K.
    Vitamin B6 salvage enzymes: mechanism, structure and regulation (2011), Biochim. Biophys. Acta, 1814, 1597-1608.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R229W the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens
R95C the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens
R95H the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal 5'-phosphate competitive inhibitor Escherichia coli
pyridoxal 5'-phosphate competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyridoxamine 5'-phosphate + H2O + O2 Escherichia coli
-
pyridoxal 5'-phosphate + NH3 + H2O2
-
?
pyridoxamine 5'-phosphate + H2O + O2 Homo sapiens
-
pyridoxal 5'-phosphate + NH3 + H2O2
-
?
pyridoxine 5'-phosphate + H2O + O2 Homo sapiens
-
pyridoxal 5'-phosphate + H2O2
-
?
pyridoxine 5'-phosphate + H2O + O2 Escherichia coli preferred substrate pyridoxal 5'-phosphate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridoxamine 5'-phosphate + H2O + O2
-
Escherichia coli pyridoxal 5'-phosphate + NH3 + H2O2
-
?
pyridoxamine 5'-phosphate + H2O + O2
-
Homo sapiens pyridoxal 5'-phosphate + NH3 + H2O2
-
?
pyridoxine 5'-phosphate + H2O + O2
-
Homo sapiens pyridoxal 5'-phosphate + H2O2
-
?
pyridoxine 5'-phosphate + H2O + O2 preferred substrate Escherichia coli pyridoxal 5'-phosphate + H2O2
-
?

Subunits

Subunits Comment Organism
homodimer
-
Escherichia coli
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
PNP oxidase
-
Escherichia coli
PNP oxidase
-
Homo sapiens
PNPOx
-
Escherichia coli
PNPOx
-
Homo sapiens
pyridoxine (pyridoxamine) 5'-phosphate oxidase
-
Escherichia coli
pyridoxine (pyridoxamine) 5'-phosphate oxidase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FMN dependent on Escherichia coli
FMN dependent on Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
pyridoxal 5'-phosphate pH and temperature not specified in the publication Homo sapiens
0.008
-
pyridoxal 5'-phosphate pH and temperature not specified in the publication Escherichia coli