Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-amphetamine | reversible competitive inhibitor | Homo sapiens | |
2-(4,5-dihydroimidazol-2-yl)-isoquinoline | reversible non-competitive/mixed inhibitor | Homo sapiens | |
2-(4,5-dihydroimidazol-2-yl)-quinoline | reversible non-competitive/mixed inhibitor | Homo sapiens | |
2-(5,7-dibromobenzofuran-2-yl)-imidazoline | reversible non-competitive/mixed inhibitor | Homo sapiens | |
amitriptyline | competive inhibition with 2-phenylethylamine as substrate | Homo sapiens | |
di(2-hydroxyethyl)methyldodecylammonium | reversible competitive inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic constants for pure hMAO-B oxidising different substrates in the presence of reversible competitive inhibitors or reversible non-competitive/mixed inhibitors | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27338 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species | Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
4-phenylbutylamine + H2O + O2 | proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species | Homo sapiens | 4-phenylbutanal + NH3 + H2O2 | - |
? | |
benzylamine + H2O + O2 | proposed pathways for amine oxidation: the amine substrate may bind to oxidised enzyme (E/FADox), leading to the release of product imine via a binary (1) or ternary (2) pathway. The relative contributions of these pathways cannot be determined directly by steady-state approaches. In following pathway 1, the unoccupied reduced enzyme (E/FADred) is generated, to which substrate may also bind. Reoxidation of the E/FADredS species (pathway 3) bypasses direct regeneration of E/FADox, with the consequence that imine released subsequent to this step, whether through the binary or ternary pathways leading from E/FADredimine, is a product of substrate binding to a second enzyme species | Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic constants for pure hMAO-B oxidising different substrates in the presence of reversible competitive inhibitors or reversible non-competitive/mixed inhibitors | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic constants for pure hMAO-B oxidising different substrates in the presence of reversible competitive inhibitors or reversible non-competitive/mixed inhibitors | Homo sapiens | |
0.00298 | - |
di(2-hydroxyethyl)methyldodecylammonium | 30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine or benzylamine | Homo sapiens | |
0.00374 | - |
di(2-hydroxyethyl)methyldodecylammonium | 30°C, pH 7, oxidative half-reaction, substrate: 4-phenylbutylamine | Homo sapiens | |
0.008 | - |
2-(5,7-dibromobenzofuran-2-yl)-imidazoline | 30°C, pH 7, oxidative half-reaction, substrate: benzylamine | Homo sapiens | |
0.0177 | - |
amitriptyline | 30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
0.0652 | - |
2-(4,5-dihydroimidazol-2-yl)-isoquinoline | 30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
0.0799 | - |
di(2-hydroxyethyl)methyldodecylammonium | 30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine, benzylamine or 4-phenylbutylamine | Homo sapiens | |
0.0817 | - |
2-(4,5-dihydroimidazol-2-yl)-quinoline | 30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
0.114 | - |
2-(5,7-dibromobenzofuran-2-yl)-imidazoline | 30°C, pH 7, reductive half-reaction, substrate: benzylamine | Homo sapiens | |
0.385 | - |
2-(4,5-dihydroimidazol-2-yl)-quinoline | 30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
0.506 | - |
(+)-amphetamine | 30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine or benzylamine | Homo sapiens | |
0.513 | - |
2-(4,5-dihydroimidazol-2-yl)-isoquinoline | 30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
0.55 | - |
amitriptyline | 30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine | Homo sapiens | |
2.56 | - |
(+)-amphetamine | 30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine or benzylamine | Homo sapiens |