Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Deprenyl | inhibits the enzyme in vivo by 34-70% depending on the age, reversible by 4-chlorophenylalanine. Deprenyl administration decreases locomotion, altered vertical positioning and increased heart rate in larvae in vivo, 4-chlorophenylalanine normalizes serotonin levels and rescues the behavioral alteration | Danio rerio |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
serotonin + H2O + O2 | Danio rerio | MAO-A | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | Danio rerio Turku | MAO-A | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
of Turku strain | - |
Danio rerio Turku | - |
of Turku strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus | Danio rerio | - |
hypothalamus | MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus | Danio rerio | - |
larva | development of MAO expression follows a similar time course as the serotonin system | Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
serotonin + H2O + O2 | MAO-A | Danio rerio | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | MAO-A | Danio rerio Turku | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO | - |
Danio rerio |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Danio rerio |