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Literature summary for 1.4.3.4 extracted from

  • Izumi, T.; Iwamoto, N.; Kitaichi, Y.; Kato, A.; Inoue, T.; Koyama, T.
    Effects of co-administration of antidepressants and monoamine oxidase inhibitors on 5-HT-related behavior in rats (2007), Eur. J. Pharmacol., 565, 105-112.
    View publication on PubMed

Application

Application Comment Organism
medicine non-selective MAO and selective MAO-A inhibitors can induce 5-hydroxytryptamine syndrome in humans when co-administered with antidepressants. Furthermore, the risk of 5-hydroxytryptamine syndrome may be lower with the selective MAO-B inhibitor selegiline Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Clorgyline the reversible and selective MAO-A inhibitor produces increases in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats Rattus norvegicus
Pargyline the irreversible and non-selective MAO inhibitor produces increases in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats Rattus norvegicus
selegiline administration of the irreversible and selective MAO-B inhibitor selegiline does not produce any increase in 5-hydroxytryptamine syndrome in the 5-hydroxytryptamine-treated rats, compared with the saline control Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-
Rattus norvegicus P19643
-
-
Rattus norvegicus P21396
-
-

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
MAO-A
-
Rattus norvegicus
MAO-B
-
Homo sapiens
MAO-B
-
Rattus norvegicus
monoamine oxidase A
-
Homo sapiens
monoamine oxidase A
-
Rattus norvegicus
monoamine oxidase B
-
Homo sapiens
monoamine oxidase B
-
Rattus norvegicus