Literature summary for 1.4.3.4 extracted from

Catto, M.; Nicolotti, O.; Leonetti, F.; Carotti, A.; Favia, A.D.; Soto-Otero, R.; Mendez-Alvarez, E.; Carotti, A.
Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches (2006), J. Med. Chem., 49, 4912-4925.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3,4-dimethyl-7-(2-phenoxyethoxy)-2H-chromen-2-one	pIC50 for MAO-A: 4.99; pIC50 for MAO-B: 7.57	Rattus norvegicus
3,4-dimethyl-7-(2-phenylethyl)-2H-chromen-2-one	pIC50 for MAO-A: 5.15; pIC50 for MAO-B: 6.34	Rattus norvegicus
3,4-dimethyl-7-phenoxy-2H-chromen-2-one	pIC50 for MAO-A: 4.5; pIC50 for MAO-B: 5.49	Rattus norvegicus
7-(2-hydroxy-2-phenylethyloxy)-3,4-dimethyl-2H-chromen-2-one	-	Rattus norvegicus
7-(3-chlorobenzyloxy)-3-methyl-2H-chromen-2-one	pIC50 for MAO-A: 4.9; pIC50 for MAO-B: 8.29	Rattus norvegicus
7-(3-phenylprop-2-en-1-yloxy)-3,4-dimethyl-2H-chromen-2-one	pIC50 for MAO-A: 4.5; pIC50 for MAO-B: 6.95	Rattus norvegicus
7-(benzenesulfonylmethoxy)-3,4-dimethyl-2H-chromen-2-one	pIC50 for MAO-A: 5.55; pIC50 for MAO-B: 6.06	Rattus norvegicus
7-benzenesulfonyloxy-2H-chromen-2-one	pIC50 for MAO-A: 6.35; pIC50 for MAO-B: 4.26	Rattus norvegicus
7-benzyloxy-3-methyl-2H-chromen-2-one	pIC50 for MAO-A: 5.26; pIC50 for MAO-B: 8.18	Rattus norvegicus
7-benzylsulfonyl-3,4-dimethyl-2H-chromen-2-one	pIC50 for MAO-A: 4.73; pIC50 for MAO-B: 5.56	Rattus norvegicus
7-benzylthio-3,4-dimethyl-2H-chromen-2-one	pIC50 for MAO-A: 5.0; pIC50 for MAO-B: 7.4	Rattus norvegicus
benzoic acid (2H-2-oxochromen-7-yl)methyl ester	pIC50 for MAO-A: 5.02; pIC50 for MAO-B: 5.62	Rattus norvegicus
N-(3,4-dimethyl-2H-2-oxochromen-7-yl)-N,4-dimethylbenzensulfonamide	pIC50 for MAO-A: 5.34; pIC50 for MAO-B: 4.5	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P19643	-	-
Rattus norvegicus	P21396	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kynuramine + H2O + O2	-	Rattus norvegicus	3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
MAO-A	-	Rattus norvegicus
MAO-B	-	Rattus norvegicus

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Release 2023.1 (January 2023)