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Literature summary for 1.4.3.4 extracted from

  • Egashira, T.; Takayama, F.; Sakai, K.
    Inhibition by Zn2+ of A-form monoamine oxidase in monkey brain mitochondria (2003), J. Pharm. Sci., 91, 239-245.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CdSO4 1 mM, 10% inhibition, monoamine oxidase B; 1 mM, 90% inhibition with serotonin as substrate, monoamine oxidase A Macaca fuscata
CuSO4 1 mM, 95% inhibition with serotonin as substrate, monoamine oxidase A Macaca fuscata
ZnSO4 1 mM, 10% inhibition, monoamine oxidase B; 1 mM, 85% inhibition with serotonin as substrate, competitive, reversible, monoamine oxidase A Macaca fuscata
ZnSO4 1 mM, about 20% inhibition, monoamine oxidase A Oryctolagus cuniculus
ZnSO4 1 mM, about 20% inhibition, monoamine oxidase A Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Oryctolagus cuniculus 5739
-
mitochondrion
-
Macaca fuscata 5739
-

Organism

Organism UniProt Comment Textmining
Macaca fuscata
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Oryctolagus cuniculus
-
brain
-
Macaca fuscata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2
-
Rattus norvegicus 2-phenylethanal + NH3 + H2O2
-
?
2-phenylethylamine + H2O + O2
-
Oryctolagus cuniculus 2-phenylethanal + NH3 + H2O2
-
?
2-phenylethylamine + H2O + O2
-
Macaca fuscata 2-phenylethanal + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Oryctolagus cuniculus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Macaca fuscata (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Rattus norvegicus
MAO-A
-
Oryctolagus cuniculus
MAO-A
-
Macaca fuscata
MAO-B
-
Macaca fuscata
monoamine oxidase A
-
Rattus norvegicus
monoamine oxidase A
-
Oryctolagus cuniculus
monoamine oxidase A
-
Macaca fuscata
monoamine oxidase B
-
Macaca fuscata

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00049
-
ZnSO4 monoamine oxidase A Macaca fuscata