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Literature summary for 1.4.3.4 extracted from

  • Markoglou, N.; Hsuesh, R.; Wainer, I.W.
    Immobilized enzyme reactors based upon the flavoenzymes monoamine oxidase A and B (2004), J. Chromatogr. B, 804, 295-302.
    View publication on PubMed

Application

Application Comment Organism
analysis on-line immobilized enzyme reactors can be used for the on-line screening of substances for MAO-A and substrate/inhibitor properties Homo sapiens
analysis on-line immobilized enzyme reactors can be used for the on-line screening of substrances for MAO-A and substrate/inhibitor properties Homo sapiens

General Stability

General Stability Organism
membranes containing human MAO-A can be immobilized in an immobilized artificial stationary phase with retention of enzymatic activity Homo sapiens
membranes containing human MAO-B can be immobilized in an immobilized artificial stationary phase with retention of enzymatic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R)-(-)-psi-ephedrine IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B; IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A Homo sapiens
(1S,2S)-(+)-psi-ephedrine IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A; IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B Homo sapiens
(R)-amphetamine IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B Homo sapiens
(R,S)-amphetamine IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2044
-
kynuramine pH 7.5, 37°C, soluble enzyme, monoamine oxidase A Homo sapiens
0.4065
-
kynuramine pH 7.5, 37°C, immobilized enzyme, monoamine oxidase A Homo sapiens
1.045
-
kynuramine pH 7.5, 37°C, soluble enzyme, monoamine oxidase B Homo sapiens
5.123
-
kynuramine pH 7.5, 37°C, immobilized enzyme, monoamine oxidase B Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Homo sapiens
MAO-B
-
Homo sapiens
monoamine oxidase A
-
Homo sapiens
monoamine oxidase B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0244
-
IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A Homo sapiens (R,S)-amphetamine
0.0991
-
IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A Homo sapiens (R)-amphetamine
1.77
-
IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A Homo sapiens (1S,2S)-(+)-psi-ephedrine
3
-
IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B Homo sapiens (R,S)-amphetamine
4.03
-
IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B Homo sapiens (R)-amphetamine
14.86
-
IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A Homo sapiens (1R,2R)-(-)-psi-ephedrine
88
-
IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B Homo sapiens (1R,2R)-(-)-psi-ephedrine
234
-
IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B Homo sapiens (1S,2S)-(+)-psi-ephedrine